Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Acidic chitinase primes the protective immune response to gastrointestinal nematodes.

Vannella, Kevin M; Ramalingam, Thirumalai R; Hart, Kevin M; de Queiroz Prado, Rafael; Sciurba, Joshua; Barron, Luke; Borthwick, Lee A; Smith, Allen D; Mentink-Kane, Margaret; White, Sandra; Thompson, Robert W; Cheever, Allen W; Bock, Kevin; Moore, Ian; Fitz, Lori J; Urban, Joseph F; Wynn, Thomas A.

Nat Immunol ; 17(5): 538-44, 2016 May.

Artigo em Inglês | MEDLINE | ID: mdl-27043413

2.

Fibrosis: from mechanisms to medicines.

Henderson, Neil C; Rieder, Florian; Wynn, Thomas A.

Nature ; 587(7835): 555-566, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-33239795

3.

Macrophages in Tissue Repair, Regeneration, and Fibrosis.

Wynn, Thomas A; Vannella, Kevin M.

Immunity ; 44(3): 450-462, 2016 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-26982353

4.

Type 2 Interleukin-4 Receptor Signaling in Neutrophils Antagonizes Their Expansion and Migration during Infection and Inflammation.

Woytschak, Janine; Keller, Nadia; Krieg, Carsten; Impellizzieri, Daniela; Thompson, Robert W; Wynn, Thomas A; Zinkernagel, Annelies S; Boyman, Onur.

Immunity ; 45(1): 172-84, 2016 07 19.

Artigo em Inglês | MEDLINE | ID: mdl-27438770

5.

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis.

Gieseck, Richard L; Ramalingam, Thirumalai R; Hart, Kevin M; Vannella, Kevin M; Cantu, David A; Lu, Wei-Yu; Ferreira-González, Sofía; Forbes, Stuart J; Vallier, Ludovic; Wynn, Thomas A.

Immunity ; 45(1): 145-58, 2016 07 19.

Artigo em Inglês | MEDLINE | ID: mdl-27421703

6.

Stricturing Crohn's Disease Single-Cell RNA Sequencing Reveals Fibroblast Heterogeneity and Intercellular Interactions.

Mukherjee, Pranab K; Nguyen, Quang Tam; Li, Jiannan; Zhao, Shuai; Christensen, Stephen M; West, Gail A; Chandra, Jyotsna; Gordon, Ilyssa O; Lin, Sinan; Wang, Jie; Mao, Ren; Czarnecki, Douglas; Rayan, Carla; Goren, Idan; Banerjee, Suhanti; Kotak, Prerna; Plesec, Thomas; Lal, Samir; Fabre, Thomas; Asano, Shoh; Bound, Kathryn; Hart, Kevin; Park, Chanyoung; Martinez, Robert; Dower, Ken; Wynn, Thomas A; Hu, Shaomin; Naydenov, Nayden; Decaris, Martin; Turner, Scott; Holubar, Stefan D; Steele, Scott R; Fiocchi, Claudio; Ivanov, Andrei I; Kravarik, Kellie M; Rieder, Florian.

Gastroenterology ; 165(5): 1180-1196, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37507073

7.

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils.

Galli, Stephen J; Borregaard, Niels; Wynn, Thomas A.

Nat Immunol ; 12(11): 1035-44, 2011 Oct 19.

Artigo em Inglês | MEDLINE | ID: mdl-22012443

8.

Macrophage activation and polarization: nomenclature and experimental guidelines.

Murray, Peter J; Allen, Judith E; Biswas, Subhra K; Fisher, Edward A; Gilroy, Derek W; Goerdt, Sergij; Gordon, Siamon; Hamilton, John A; Ivashkiv, Lionel B; Lawrence, Toby; Locati, Massimo; Mantovani, Alberto; Martinez, Fernando O; Mege, Jean-Louis; Mosser, David M; Natoli, Gioacchino; Saeij, Jeroen P; Schultze, Joachim L; Shirey, Kari Ann; Sica, Antonio; Suttles, Jill; Udalova, Irina; van Ginderachter, Jo A; Vogel, Stefanie N; Wynn, Thomas A.

Immunity ; 41(1): 14-20, 2014 Jul 17.

Artigo em Inglês | MEDLINE | ID: mdl-25035950

9.

Regional Differences in Human Biliary Tissues and Corresponding In Vitro-Derived Organoids.

Rimland, Casey A; Tilson, Samantha G; Morell, Carola M; Tomaz, Rute A; Lu, Wei-Yu; Adams, Simone E; Georgakopoulos, Nikitas; Otaizo-Carrasquero, Francisco; Myers, Timothy G; Ferdinand, John R; Gieseck, Richard L; Sampaziotis, Fotios; Tysoe, Olivia C; Ross, Alexander; Kraiczy, Judith M; Wesley, Brandon; Muraro, Daniele; Zilbauer, Matthias; Oniscu, Gabriel C; Hannan, Nicholas R F; Forbes, Stuart J; Saeb-Parsy, Kourosh; Wynn, Thomas A; Vallier, Ludovic.

Hepatology ; 73(1): 247-267, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-32222998

10.

Metformin and 2-Deoxyglucose Collaboratively Suppress Human CD4⁺ T Cell Effector Functions and Activation-Induced Metabolic Reprogramming.

Tan, Stefanie Y; Kelkar, Yogeshwar; Hadjipanayis, Angela; Shipstone, Arun; Wynn, Thomas A; Hall, J Perry.

J Immunol ; 205(4): 957-967, 2020 08 15.

Artigo em Inglês | MEDLINE | ID: mdl-32641388

11.

Basophils trump dendritic cells as APCs for T(H)2 responses.

Wynn, Thomas A.

Nat Immunol ; 10(7): 679-81, 2009 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-19536189

12.

Mechanisms of Organ Injury and Repair by Macrophages.

Vannella, Kevin M; Wynn, Thomas A.

Annu Rev Physiol ; 79: 593-617, 2017 02 10.

Artigo em Inglês | MEDLINE | ID: mdl-27959618

13.

Heat shock protein 70 is a positive regulator of airway inflammation and goblet cell hyperplasia in a mouse model of allergic airway inflammation.

Yombo, Dan J K; Mentink-Kane, Margaret M; Wilson, Mark S; Wynn, Thomas A; Madala, Satish K.

J Biol Chem ; 294(41): 15082-15094, 2019 10 11.

Artigo em Inglês | MEDLINE | ID: mdl-31431507

14.

Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection.

Sutherland, Tara E; Rückerl, Dominik; Logan, Nicola; Duncan, Sheelagh; Wynn, Thomas A; Allen, Judith E.

PLoS Pathog ; 14(11): e1007423, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30500858

15.

Myeloid-cell differentiation redefined in cancer.

Wynn, Thomas A.

Nat Immunol ; 14(3): 197-9, 2013 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-23416669

16.

Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain.

Ramalingam, Thirumalai R; Pesce, John T; Sheikh, Faruk; Cheever, Allen W; Mentink-Kane, Margaret M; Wilson, Mark S; Stevens, Sean; Valenzuela, David M; Murphy, Andrew J; Yancopoulos, George D; Urban, Joseph F; Donnelly, Raymond P; Wynn, Thomas A.

Nat Immunol ; 9(1): 25-33, 2008 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-18066066

17.

Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.

El Kasmi, Karim C; Qualls, Joseph E; Pesce, John T; Smith, Amber M; Thompson, Robert W; Henao-Tamayo, Marcela; Basaraba, Randall J; König, Till; Schleicher, Ulrike; Koo, Mi-Sun; Kaplan, Gilla; Fitzgerald, Katherine A; Tuomanen, Elaine I; Orme, Ian M; Kanneganti, Thirumala-Devi; Bogdan, Christian; Wynn, Thomas A; Murray, Peter J.

Nat Immunol ; 9(12): 1399-406, 2008 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-18978793

18.

Opinion on Immune Tolerance Therapeutic Development.

Radi, Zaher A; Wynn, Thomas A.

Toxicol Pathol ; 48(6): 712-717, 2020 08.

Artigo em Inglês | MEDLINE | ID: mdl-32815472

19.

Fibroblast-specific integrin-alpha V differentially regulates type 17 and type 2 driven inflammation and fibrosis.

Sciurba, Joshua C; Gieseck, Richard L; Jiwrajka, Nikhil; White, Sandra D; Karmele, Erik P; Redes, Jamie; Vannella, Kevin M; Henderson, Neil C; Wynn, Thomas A; Hart, Kevin M.

J Pathol ; 248(1): 16-29, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30536905

20.

Two types of fibroblast drive arthritis.

Wynn, Thomas A.

Nature ; 570(7760): 169-170, 2019 06.

Artigo em Inglês | MEDLINE | ID: mdl-31182828

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Acidic chitinase primes the protective immune response to gastrointestinal nematodes.

Fibrosis: from mechanisms to medicines.

Macrophages in Tissue Repair, Regeneration, and Fibrosis.

Type 2 Interleukin-4 Receptor Signaling in Neutrophils Antagonizes Their Expansion and Migration during Infection and Inflammation.

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis.

Stricturing Crohn's Disease Single-Cell RNA Sequencing Reveals Fibroblast Heterogeneity and Intercellular Interactions.

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils.

Macrophage activation and polarization: nomenclature and experimental guidelines.

Regional Differences in Human Biliary Tissues and Corresponding In Vitro-Derived Organoids.

Metformin and 2-Deoxyglucose Collaboratively Suppress Human CD4⁺ T Cell Effector Functions and Activation-Induced Metabolic Reprogramming.

Basophils trump dendritic cells as APCs for T(H)2 responses.

Mechanisms of Organ Injury and Repair by Macrophages.

Heat shock protein 70 is a positive regulator of airway inflammation and goblet cell hyperplasia in a mouse model of allergic airway inflammation.

Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection.

Myeloid-cell differentiation redefined in cancer.

Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain.

Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.

Opinion on Immune Tolerance Therapeutic Development.

Fibroblast-specific integrin-alpha V differentially regulates type 17 and type 2 driven inflammation and fibrosis.

Two types of fibroblast drive arthritis.